Tangential Flow Filtration Industry

The global tangential flow filtration market size is projected to reach USD 4.13 billion by 2030, registering a growth at a CAGR of 12.4% from 2025 to 2030, according to a new report published by Grand View Research, Inc. The primary factors contributing to this market expansion include the benefits offered by tangential flow filtration (TFF) compared to normal flow filtration, the rising demand for vaccines and therapeutics produced through bioprocessing operations, and the increasing investments in comprehensive research and development activities aimed at creating new technologies within the TFF sector.

The utilization of TFF technology witnessed a significant rise during the COVID-19 pandemic, as this separation process was extensively employed in vaccine production activities. Products related to TFF experienced heightened adoption rates during COVID-19 research endeavors focused on developing and manufacturing vaccines as part of various treatment strategies. Furthermore, the pandemic period observed a surge in the use of single-use bioprocessing systems, which contributed substantially to the expansion of the market. Additionally, multiple initiatives were undertaken by governments and leading manufacturers to enhance vaccine development efforts intended to control the spread of the SARS-CoV-2 infection. For example, in April 2021, Meissner Filtration Products, Inc. announced that it had secured a contract worth USD 13.4 million from the U.S. government agency BARDA (Biomedical Advanced Research and Development Authority) to expand its production capacity and manufacture single-use systems supporting the vaccine manufacturing process for COVID-19. As a result, the increased production of vaccines has significantly boosted the demand for TFF products, thereby driving their market growth.

Tangential flow filtration, often also called cross-flow filtration, is a technique utilized for the separation and purification of molecules, in which the feed solution moves parallel to the membrane filter. During this filtration process, a portion of the flow stream passes through the membrane, while the remaining part becomes concentrated through recirculation within the system. TFF technology finds application across both upstream and downstream bioprocessing stages due to its numerous advantages, such as lower operating costs, better operational control and efficiency, reduced chances of cross-contamination, ease of scaling operations up or down, and extended shelf life of the products. These benefits have supported the application of TFF across a wide array of scientific fields including biochemistry, molecular biology, and immunology.

Moreover, the increasing demand for biopharmaceuticals, driven by their reduced side effects, availability of personalized treatment options, and the emergence of novel therapies, has led to the expansion of manufacturing capacities. Contract Manufacturing Organizations (CMOs) and Contract Research Organizations (CROs) have also experienced a rise in the production of vaccines and therapeutics, fueled by the heightened demand for commercial biopharmaceuticals.

For instance, in June 2022, Merck KGaA announced the expansion of its existing CDMO (Contract Development and Manufacturing Organization) facility located in Wisconsin, USA. This new project, with an investment of USD 58 million (equivalent to EUR 59 million), aims to enhance the production capacity of highly potent active pharmaceutical ingredients to cater to the growing demand for therapies addressing critical cancers. The increase in the manufacturing and demand for biopharmaceuticals has significantly contributed to the adoption of TFF products in harvesting, separation, and purification processes, thus propelling the growth of the overall market.

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Tangential Flow Filtration Market Segments Highlights:

1. Single-use tangential flow filtration (TFF) systems led the market and accounted for the largest revenue share of 42.0% in 2024 attributed to the increasing adoption of single-use technologies across pharmaceutical companies, contract organizations, and research institutions.

2. Ultrafiltration technology dominated the market and accounted for the largest revenue share, 55.8%, in 2024, owing to the rising demand for ultrapure water in the food and beverage, pharmaceuticals, and wastewater treatment sectors. In addition, stringent regulatory requirements regarding water quality and environmental sustainability compel industries to implement advanced filtration technologies.

3. Raw material filtration led the market and accounted for the largest revenue share in 2024, owing to the increasing demand for high-quality raw materials across various industries, particularly in pharmaceuticals and food and beverage.

4. Pharmaceutical and biotechnology companies dominated the market and accounted for the largest revenue share of 44.0% in 2024 attributed primarily to the increasing demand for biopharmaceuticals.

Tangential Flow Filtration Market Report Segmentation

Grand View Research has segmented the global tangential flow filtration market based on product, technology, application, end-use, and region:

Tangential Flow Filtration Product Outlook (Revenue, USD Million, 2018 - 2030)

1. Single-use Tangential Flow Filtration Systems

2. Reusable Tangential Flow Filtration Systems

3. Membrane Filters

   1. Polyethersulfone (PES)

   2. Polyvinylidene Difluoride (PVDF)

   3. Polytetrafluoroethylene (PTFE)

   4. Mixed Cellulose Ester & Cellulose Acetate

   5. Polycarbonate Tracked Etched (PCTE)

   6. Regenerated Cellulose

   7. Others

4. Filtration Accessories

Tangential Flow Filtration Technology Outlook (Revenue, USD Million, 2018 - 2030)

1. Ultrafiltration

2. Microfiltration

3. Nanofiltration

4. Others

Tangential Flow Filtration Application Outlook (Revenue, USD Million, 2018 - 2030)

1. Protein Purification

2. Vaccine And Viral Vectors

3. Antibody Purification

4. Raw Material Filtration

5. Others

Tangential Flow Filtration End-use Outlook (Revenue, USD Million, 2018 - 2030)

1. Pharmaceutical & Biotechnology Companies

2. Contract Research Organizations & Contract Manufacturing Organizations

3. Academic Institutes & Research Laboratories

Tangential Flow Filtration Regional Outlook (Revenue, USD Million, 2018 - 2030)

1. North America

   1. US

   2. Canada

   3. Mexico

2. Europe

   1. UK

   2. Germany

   3. France

   4. Italy

   5. Spain

   6. Denmark

   7. Sweden

   8. Norway

3. Asia Pacific

   1. India

   2. Japan

   3. China

   4. Australia

   5. South Korea

   6. Thailand

4. Latin America

   1. Brazil

   2. Argentina

5. Middle East and Africa (MEA)

   1. Kuwait

   2. Saudi Arabia

   3. UAE

   4. South Africa

Key Tangential Flow Filtration Company Insights

1. Danaher Corporation

2. Sartorius AG

3. Parker-Hannifin Corporation

4. Alfa Laval AG

5. Merck KGaA

6. Repligen Corporation

7. FUJIFILM Wako Pure Chemical Corporation

8. ABEC, Inc.

9. Sterlitech Corporation

10. Synder Filtration, Inc.

11. Meissner Filtration Products, Inc.

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